Scientists have searched for mutations in more than 100 kidney cancer samples, the largest number of samples from a single tumor type to be sequenced to date. They looked for mutations in 3,544 genes to investigate the complexity within this cancer type, which is typically associated with mutations in a gene called VHL. Despite this prevalent genetic signature, the team revealed substantial genetic heterogeneity, suggesting that a complex machinery contributes to the development of cancer.
Unraveling kidney cancer: Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma
January 10th, 2010 by Newspublichealth.com
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