Results of a preliminary study show that “mini” stem cell transplantation may safely reverse severe sickle cell disease in adults.
Archive for December, 2009
‘Mini’ transplant may reverse severe sickle cell disease
Treating cluster headaches with high-flow oxygen appears effective
Patients with a cluster headache, which is characterized by bouts of excruciating pain usually near the eye or temple, were more likely to report being pain-free within 15 minutes of treatment with high-flow oxygen than patients who received a placebo treatment, according to a new study.
Patients lack knowledge of medications they were given in hospital, study shows
In a new study to asses patient awareness of medications prescribed during a hospital visit, 44 percent of patients believed they were receiving a medication they were not, and 96 percent were unable to recall the name of at least one medication that they had been prescribed during hospitalization.
Potential cancer drug may offer new hope for asthma patients
A drug being tested to treat cancer could also help patients suffering from asthma, research has suggested. Scientists found that the drug — R-roscovitine — helps to kill certain immune cells which can exacerbate symptoms associated with asthma.
Delivering medicine directly into a tumor
Researchers have identified a peptide (a chain of amino acids) that specifically recognizes and penetrates cancerous tumors but not normal tissues. The peptide was also shown to deliver diagnostic particles and medicines into the tumor.
Advances in diagnosing and treating leukemia and myeloproliferative disorders
Leukemia and myeloproliferative disorders are serious and often deadly blood cancers. Recent research introduces potential new treatment options and improved diagnostic methods for patients suffering from acute promyelocytic leukemia, chronic myeloid leukemia, infant acute lymphoblastic leukemia, and myelofibrosis that are based on a better understanding of the underlying genetic causes of these conditions.
Dermatologic infections in cancer patients treated with EGFRI therapy
Patients who experience dermatologic toxic effects from epidermal growth factor receptor inhibitors (EGFRIs) have a high prevalence of skin and nail infections, according to a new study.
New clues emerge for understanding morphine addiction
Scientists are adding additional brush strokes to the revolutionary new image now emerging for star-shaped cells called astrocytes in the brain and spinal cord. Their report suggests a key role for astrocytes in morphine’s ability to relieve pain and cause addiction.
New target for lymphoma therapy
Researchers have discovered how an oncogene gets activated in mature B cells, suggesting a new target for therapy in B cell lymphomas. The study marks the first time researchers have understood how the over-activation of c-myc can lead to blood-related cancers.
New mouse could help understand how some lung cancer cells evade drug treatment
A new study describes the development of drug resistance in mice with lung cancer. The lung tumors in mice result from changes similar to those seen in human patients. Also like humans, these tumors initially respond to drug treatment but eventually become resistant to therapy. Studying lung cancer cells in this model should provide insight into the mechanisms that make lung cancer cells resistant to current treatment methods and uncover new therapeutic targets.
HIV-related memory loss linked to Alzheimer’s protein
More than half of HIV patients experience memory problems and other cognitive impairments as they age, and doctors know little about the underlying causes. New research suggests HIV-related cognitive deficits share a common link with Alzheimer’s-related dementia: low levels of the protein amyloid beta in the spinal fluid.
Small addition to cancer drug may make big difference
The addition of a small molecule to the cancer drug Temozolomide disrupts repair mechanisms in a type of tumor cells that is highly resistant to treatment.
Rodent smoke screen: Rat model shows tobacco smoke exposure induces brain changes indicative of nicotine dependence
Rats passively exposed to tobacco smoke become dependent on nicotine, according to a new study. The findings of how rats’ brains respond to exposure to tobacco smoke have implications for the study of the effects of tobacco smoke on the human brain and for future studies testing new treatments for tobacco addiction.
‘Rational drug design’ identifies fragments of FDA-approved drugs relevant to emerging viruses
A massive, data-crunching computer search program that matches fragments of potential drug molecules to the known shapes of viral surface proteins has identified several FDA-approved drugs that could be the basis for new medicines — if emerging viruses such as the H5N1 (avian flu) or H1N1/09 (swine flu) develop resistance to current antiviral therapies.
New platinum compound shows promise in tumor cells
Chemists have developed a new platinum compound that is as powerful as the commonly used anticancer drug cisplatin but better able to destroy tumor cells.
Strategies to protect new brain cells against Alzheimer’s disease
Scientists have discovered that two main causes of AD amyloid-beta (A²) peptides and apolipoprotein E4 (apoE4) impair the growth of new neurons born in adult brains. What is more, they have identified drug treatments that can normalize the development of these cells even in the presence of A² or apoE4.
Recreational drug use is related to impulsive behavior, Spanish research reveals
Psychologists in Spain have just concluded a study regarding the use of addictive substances by young university students and the manifestation of impulsive behavior in the same group of people, on a cognitive and psychomotor level. The findings suggest that regular consumers of cannabis and alcohol are more impulsive than non-users. However, there is no evidence of the differences between both of these consumer groups, which makes these experts believe that “consuming these substances, whatever their nature, is related to impulsivity.”
First multilingual overview of ‘Spice’ drugs raises new concerns
Recent research into the availability of ‘Spice’ drugs online raises new concerns about its mood altering effects.
Many dialysis patients undergoing PCI receive improper medication, with higher risk of bleeding
Approximately 20 percent of dialysis patients undergoing a percutaneous coronary intervention (PCI; procedure such as angioplasty) are given an antithrombotic medication they should not receive, which may increase their risk for in-hospital bleeding, according to a new study.
Researchers launch phase II trial of stem cells and acute heart attack
The second phase of a clinical trial testing a new stem-cell-based therapy on injured heart muscle has been launched by researchers at the University of Texas Medical School at Houston.
Possible ovarian cancer treatment target identified
A multi-institutional study has identified a potential personalized treatment target for the most common form of ovarian cancer. The research team discovered that a gene called MAGP2 — not previously associated with any type of cancer — was overexpressed in papillary serous ovarian tumors of patients who died more quickly. They also found evidence suggesting possible mechanisms by which MAGP2 may promote tumor growth.
Sonic Hedgehog variations linked to recurrence, survival and response to therapy of bladder cancer
Genetic variations in the Sonic Hedgehog pathway increase the likelihood of recurrence, reduce survival time and limit response to therapy for people with non-muscle invasive bladder cancer, scientists report.
New mouse could help understand how some lung cancer cells evade drug treatment
A new study describes the development of drug resistance in mice with lung cancer. The lung tumors in mice result from changes similar to those seen in human patients. Also like humans, these tumors initially respond to drug treatment but eventually become resistant to therapy. Studying lung cancer cells in this model should provide insight into the mechanisms that make lung cancer cells resistant to current treatment methods and uncover new therapeutic targets.
Genetic predeterminants for diabetes in African-Americans identified
Researchers say a recent discovery suggests that inherited genetic variations exist between whites and blacks living in the US, leading to less efficient metabolism of glucose and predisposition to diabetes in blacks.
Type 2 diabetes gene predisposes children to obesity, study finds
Pediatric researchers have found that a gene already implicated in the development of type 2 diabetes in adults also raises the risk of being overweight during childhood. The finding sheds light on the genetic origins of diabetes and may present an avenue for developing drugs to counteract the disease, which has been on the upswing in childhood and adolescence.
Higher risk for heart disease and diabetes associated with androgen deprivation therapy
Men of all ages treated for prostate cancer with androgen deprivation therapy, specifically with gonadotropin-releasing hormone agonists, have an increased risk of diabetes and cardiovascular disease, according to a new study.
Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
Eighteen single-point genetic variations indicate risk of recurrence for early-stage head and neck cancer patients and their likelihood of developing a second type of cancer, researchers report.
Treating cluster headaches with high-flow oxygen appears effective
Patients with a cluster headache, which is characterized by bouts of excruciating pain usually near the eye or temple, were more likely to report being pain-free within 15 minutes of treatment with high-flow oxygen than patients who received a placebo treatment, according to a new study.
New approach to treat lower back pain unveiled
Using a branch of science that crosses disciplines to study complex problems, a researcher is introducing a new way to understand and treat lower back pain, a condition affecting more than 40 million Americans and costing billions of dollars each year.
H1N1 more risky than seasonal flu in children with sickle cell disease
Infection with the H1N1 virus, or swine flu, causes more life-threatening complications than seasonal flu in children with sickle cell disease, according to new research. The findings warn parents and caregivers that such children are more likely to need emergency treatment and stays in an intensive-care unit.
New clues emerge for understanding morphine addiction
Scientists are adding additional brush strokes to the revolutionary new image now emerging for star-shaped cells called astrocytes in the brain and spinal cord. Their report suggests a key role for astrocytes in morphine’s ability to relieve pain and cause addiction.
Small addition to cancer drug may make big difference
The addition of a small molecule to the cancer drug Temozolomide disrupts repair mechanisms in a type of tumor cells that is highly resistant to treatment.
Hidden sensory system discovered in the skin
Researchers report that the human body has an entirely unique and separate sensory system aside from the nerves that give most of us the ability to touch and feel. Surprisingly, this sensory network is located throughout our blood vessels and sweat glands, and is for most people, largely imperceptible. This discovery may shed light on the causes of unexplained chronic pain conditions such as fibromyalgia.
Coaxing injured nerve fibers to regenerate by disabling ‘brakes’ in the system
Expanding on prior research, scientists provide further evidence that regeneration of nerve fibers after brain or spinal cord injury is limited by a lack of response to growth factors induced by the injury. They show in mice that axons can regenerate vigorously when responsiveness is restored genetically — a finding that could lead to ways of helping people recover from brain or spinal cord injury.
First evidence of brain rewiring in children: Reading remediation positively alters brain tissue
Scientists have uncovered the first evidence that intensive instruction to improve reading skills in young children causes the brain to physically rewire itself, creating new white matter that improves communication within the brain.
New skin stem cells surprisingly similar to those found in embryos
Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage and even nerve cells.
Stem cell derived neurons for research relevant to Alzheimer’s and Niemann-Pick type C diseases
Stem cell derived neurons may allow scientists to determine whether breakdowns in the transport of proteins, lipids and other materials within cells trigger the neuronal death and neurodegeneration that characterize Alzheimer’s disease and the rarer but always fatal neurological disorder, Niemann-Pick Type C, according to a recent presentation. Early defects in the intracellular physical transport system may be the driving force behind severe neuronal dysfunction.
Nerve-cell transplants help brain-damaged rats fully recover lost ability to learn
Nerve cells transplanted into brain-damaged rats helped them to fully recover their ability to learn and remember, probably by promoting nurturing, protective growth factors, according to a new study.
The thalamus, middleman of the brain, becomes a sensory conductor
Two new studies show that the thalamus — the small central brain structure often characterized as a mere pit-stop for sensory information on its way to the cortex — is heavily involved in sensory processing, and is an important conductor of the brain’s complex orchestra. Published in Nature Neuroscience and the Proceedings of the National Academy of Sciences, the two studies demonstrate the important role of the thalamus in shaping what humans see, hear and feel.
New clues emerge for understanding morphine addiction
Scientists are adding additional brush strokes to the revolutionary new image now emerging for star-shaped cells called astrocytes in the brain and spinal cord. Their report suggests a key role for astrocytes in morphine’s ability to relieve pain and cause addiction.
HIV-related memory loss linked to Alzheimer’s protein
More than half of HIV patients experience memory problems and other cognitive impairments as they age, and doctors know little about the underlying causes. New research suggests HIV-related cognitive deficits share a common link with Alzheimer’s-related dementia: low levels of the protein amyloid beta in the spinal fluid.
Rodent smoke screen: Rat model shows tobacco smoke exposure induces brain changes indicative of nicotine dependence
Rats passively exposed to tobacco smoke become dependent on nicotine, according to a new study. The findings of how rats’ brains respond to exposure to tobacco smoke have implications for the study of the effects of tobacco smoke on the human brain and for future studies testing new treatments for tobacco addiction.
First evidence of brain rewiring in children: Reading remediation positively alters brain tissue
Scientists have uncovered the first evidence that intensive instruction to improve reading skills in young children causes the brain to physically rewire itself, creating new white matter that improves communication within the brain.
Children who survive cancer more likely to suffer from heart disease
Children and adolescents who survive cancer have a significantly higher risk of developing heart disease as young adults, according to a new large study.
Neurosurgeons draft new treatment guidelines for brain metastases
New treatment guidelines for patients with brain metastases are now available. This new, significant tool aims to improve the quality of care for patients who suffer from brain tumors.
Delivering medicine directly into a tumor
Researchers have identified a peptide (a chain of amino acids) that specifically recognizes and penetrates cancerous tumors but not normal tissues. The peptide was also shown to deliver diagnostic particles and medicines into the tumor.
Most antidepressants miss key target of clinical depression, study finds
Most current antidepressants do not address a key brain chemical, monoamine oxidase-A, according to a new study.
The thalamus, middleman of the brain, becomes a sensory conductor
Two new studies show that the thalamus — the small central brain structure often characterized as a mere pit-stop for sensory information on its way to the cortex — is heavily involved in sensory processing, and is an important conductor of the brain’s complex orchestra. Published in Nature Neuroscience and the Proceedings of the National Academy of Sciences, the two studies demonstrate the important role of the thalamus in shaping what humans see, hear and feel.
Ubiquitous health: Enabling telemedicine to cut hospital visits, save money
A ubiquitous health monitoring system that automatically alerted the patient’s family or physician to problematic changes in the person’s vital signs could cut hospital visits and save lives, according to Japanese researchers.
Turning metal black more than just a novelty: Laser technique could have important medical implications
Researchers made headlines recently when they changed the color of everyday metals by scouring their surfaces with precise, high-intensity laser bursts. A recent discovery has shown that beyond the aesthetic opportunities in the finding lie some very powerful potential uses, such as diagnosing some diseases with unprecedented ease and precision.